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 | Aug 07, 2021 | Stewartry RFC | Home | 2:30 pm | 17 - 10 | Report |
| Aug 14, 2021 | Ayr RFC | Away | 2:00 pm | 21 - 0 | |
| Aug 21, 2021 | East Kilbride RFC | Home | 3:00 pm | 71 - 22 | |
| Sep 04, 2021 | Falkirk RFC | Home | 3:00 pm | 29 - 26 | |
| Sep 11, 2021 | Gordonians RFC | Away | 3:00 pm | 12 - 27 | |
| Sep 18, 2021 | Hamilton RFC | Home | 3:00 pm | | |
| Sep 25, 2021 | Glasgow Academicals RFC | Away | 3:00 pm | | |
| Oct 02, 2021 | Whitecraigs RFC | Home | 3:00 pm | | |
| Oct 09, 2021 | Peebles RFC | Away | 3:00 pm | | |
| Oct 16, 2021 | Stewart’s Melville RFC | Home | 3:00 pm | | |
| Oct 23, 2021 | Preston Lodge RFC | Away | 3:00 pm | | |
| Oct 30, 2021 | Newton Stewart RFC | Home | 3:00 pm | | |
| Nov 06, 2021 | GHK RFC | Away | 2:00 pm | | |
| Nov 27, 2021 | Kirkcaldy RFC | Home | 2:00 pm | | |
| Dec 04, 2021 | Falkirk RFC | Away | 2:00 pm | | |
| Dec 11, 2021 | Gordonians RFC | Home | 2:00 pm | | |
| Jan 08, 2022 | Hamilton Bulls | Away | 2:00 pm | | |
| Jan 15, 2022 | Glasgow Academicals RFC | Home | 2:00 pm | | |
| Jan 22, 2022 | Whitecraigs RFC | Away | 2:00 pm | | |
| Jan 29, 2022 | Peebles RFC | Home | 2:00 pm | | |
| Feb 19, 2022 | Stewart’s Melville RFC | Away | 3:00 pm | | |
| Mar 05, 2022 | Preston Lodge RFC | Home | 3:00 pm | | |
| Mar 26, 2022 | Newton Stewart RFC | Away | 3:00 pm | | |
| Apr 02, 2022 | GHK RFC | Home | 3:00 pm | | |
| Apr 09, 2022 | Kirkcaldy RFC | Away | 3:00 pm | | |
